| Drug | Dose Regimen | Time to Reach Steady State |
Target Serum Concentration |
| Phenobarbital | 2-5 mg / kg 2 times / day | 10-18 days | 20-45 microgram / ml |
| Primidone | 5-10 mg / kg 3 times / day |
10-18 days | 20-45 microgram / ml (phenobarbital *c) |
| Potassium Bromide | 20 mg / kg 1 time / day | 4 months | 0.7 - 1.9 mg / ml (bromide *c) |
| Chlorazepate | 2 mg / kg 2 times / day |
NA*b | 500-1900 ng / ml *d (nordiazepam *c) |
| Valproate | 60 mg / kg 3 times / day | NA*b | 50-150 microgram / ml *d |
| Mephenytoin | 10 mg / kg 3 times / day |
5-7 days | 25-40 microgram / ml *d (5 - phenylhydantoin) |
*a). Currently, primidone and phenytoin are the only drugs labeled for the treatment of canine epilepsy. Other antiepileptic drugs must be used in an extralabel fashion. Bromide must be custom formulated, and suppliers may require the veterinarian to contact the U.S. Food and Drug Administration.*b). Not applicable; steady state is not reached at the indicated dosage frequency.*c). Represents the active metabolite or compound that should be measured.*d). Human values; canine values are not known Return to our Sitemap